Hormonal
Pharmacological inhibition of angiotensin-converting enzyme (ACE) using enalapril (20 mg/day) during 8 weeks of high-intensity training significantly attenuates exercise-induced increases in lean body mass in healthy adults, while peripheral muscle adaptations and aerobic performance remain unaffected.
If you are taking ACE inhibitors (like enalapril or lisinopril) for blood pressure, be aware that these medications may blunt your muscle growth potential compared to not taking them. This does not mean you cannot build strength or endurance, but your muscle mass gains may be reduced. Focus on consistent training and nutrition, and consult your doctor before making any medication changes.
Lean body mass increased by ~3% in the placebo group but remained unchanged with ACE inhibitor treatment, directly demonstrating that reduced ACE activity can blunt exercise-induced hypertrophy.
Why this rating
Based on a specific, well-controlled human intervention study (Sjúrðarson et al., 2022, 2023) cited in the review, though the review itself is a synthesis.
Source
Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions
Tórur Sjúrðarson et al. · The Journal of Physiology · 2025
DOI 10.1113/jp288202
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