Energy balance
Discontinuation of incretin therapy leads to weight regain that is proportional in composition (fat and lean mass) to the initial loss, challenging the belief that regained weight is predominantly fat.
If you stop your GLP-1 medication, you will likely regain weight. Contrary to popular belief, this regained weight is not just fat; it includes muscle and other lean tissue, following a similar ratio to what you lost. However, older adults may struggle to regenerate muscle, so maintaining activity is crucial.
no evidence of preferential fat regain was observed; instead, both fat and lean body mass appeared to follow the same proportional trajectory during both phases.
Why this rating
Based on systematic reviews and observational data (Biggest Loser), not long-term RCTs of GLP-1 discontinuation.
Source
Muscle Loss in Obesity Therapy as a Therapeutic Target: Trial Design and Endpoints for Regulatory Discussions
Stephan von Hörsten et al. · Journal of Cachexia Sarcopenia and Muscle · 2025
DOI 10.1002/jcsm.70147
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