Research
Hormonal
DJB implantation leads to significant improvements in liver enzymes (AST, ALT, GGT) and lipid panels (LDL, Cholesterol, HDL, TAG).
DJB implantation improves liver health (reducing enzymes like AST and ALT) and improves lipid profiles (lowering bad cholesterol and triglycerides, raising good cholesterol).
ModerateSupportsMEDIUM confidence
There was a significant change in liver enzymes (AST, ALT – p < 0.0001, GGT – p = 0.0002) and lipid panels (LDL, cholesterol – p < 0.0001, HDL – p = 0.018, TAG – p = 0.013) before implantation and after explantation.
Why this rating
Retrospective observational study.
Source
Long-term Results of Duodeno-jejunal Bypass in the Treatment of Obesity and Type 2 Diabetes
Jan Král et al. · Obesity Surgery · 2023
DOI 10.1007/s11695-023-06979-4
cohort · n=121Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Implantation of the Duodeno-Jejunal Bypass (DJB) device for 12+ months significantly reduces body weight (mean 10.3% TBWL) and BMI in obese patients (BMI ≥ 27 kg/m2).Moderate
- DJB implantation significantly improves glycemic control (HbA1c reduction) in patients with Type 2 Diabetes Mellitus.Moderate
- DJB implantation is associated with a high rate of adverse events (13.2% early extraction) and serious complications, including liver abscesses and bleeding.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →