Research
Mixed
Implantation of the Duodeno-Jejunal Bypass (DJB) device for 12+ months significantly reduces body weight (mean 10.3% TBWL) and BMI in obese patients (BMI ≥ 27 kg/m2).
The DJB device, implanted endoscopically for about a year, can help obese patients lose an average of 10% of their body weight. It is less invasive than surgery but carries a risk of complications (about 13% require early removal). It is particularly useful for patients with Type 2 Diabetes as it also improves blood sugar control.
ModerateSupportsMEDIUM confidence
The mean total body weight loss (%TBWL) after explantation was 10.3% ± 7.9% (14.2 kg, p < 0.0001), and the mean BMI was 39.5 ± 7.3 kg/m2 (p < 0.0001).
Why this rating
Retrospective observational study with a relatively large cohort (n=121) but no control group.
Source
Long-term Results of Duodeno-jejunal Bypass in the Treatment of Obesity and Type 2 Diabetes
Jan Král et al. · Obesity Surgery · 2023
DOI 10.1007/s11695-023-06979-4
cohort · n=121Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- DJB implantation significantly improves glycemic control (HbA1c reduction) in patients with Type 2 Diabetes Mellitus.Moderate
- DJB implantation leads to significant improvements in liver enzymes (AST, ALT, GGT) and lipid panels (LDL, Cholesterol, HDL, TAG).Moderate
- DJB implantation is associated with a high rate of adverse events (13.2% early extraction) and serious complications, including liver abscesses and bleeding.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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