Mixed
Patients with severe obesity carrying a high genetic risk score for waist-hip ratio (WHR GRS) experience significantly reduced weight loss from a 24-week milk-based meal replacement program compared to those with lower WHR GRS.
If you have a family history of carrying weight around your waist, standard meal replacement diets might be less effective for you than for others. This doesn't mean you can't lose weight, but you may need to manage expectations regarding the speed and magnitude of loss, or consider more intensive support. Genetic testing for waist-hip ratio risk could help tailor your approach.
The waist–hip ratio (WHR) GRS was inversely associated with percentage total weight loss at 24 weeks (adjusted β for one standard deviation increase in WHR GRS −11.6 [−23.0, −0.3], p = 0.045), and patients in the lowest tertile of WHR GRS lost more weight.
Why this rating
Single-center prospective cohort study with moderate sample size (n=93) and statistical significance, but limited generalizability to non-White populations.
Source
Higher Waist Hip Ratio Genetic Risk Score Is Associated with Reduced Weight Loss in Patients with Severe Obesity Completing a Meal Replacement Programme
Dale Handley et al. · Journal of Personalized Medicine · 2022
DOI 10.3390/jpm12111881
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →