Research
Macro partitioning
High-fat and fasting diets increase lipid oxidation (LIPOX) and lower respiratory quotient (RQ), which is directly associated with increased circulating acylcarnitines and decreased glycerophospholipids, indicating a coordinated metabolic shift toward mitochondrial beta-oxidation.
When you eat a high-fat or fasted state, your body shifts to burning fat for fuel. This shift is measurable through specific blood markers (acylcarnitines) and breathing ratios (RQ). If you want to increase fat oxidation, reducing carbohydrate intake or fasting are effective strategies.
StrongSupportsHIGH confidence
Diets exhibiting greater fat oxidation (e.g., fasting, high-fat) were associated with changes in metabolites within pathways of mitochondrial β-oxidation, ketogenesis, adipose tissue fatty acid liberation, and/or multiple anapleurotic substrates for tricarboxylic acid cycle flux, with inverse associations for diets with greater carbohydrate availability.
Why this rating
Gold-standard human metabolic chambers with precise 24-hour indirect calorimetry and metabolite profiling in a crossover design.
Source
Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition
Andrew Perry et al. · JCI Insight · 2024
crossover · n=97Cited 3×
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