Research
Energy balance
High-carbohydrate overfeeding increases 24-hour energy expenditure (EE) more than high-fat or fasting diets, despite being associated with lower lipid oxidation.
If you are overfeeding, a high-carbohydrate diet may result in higher total energy expenditure than a high-fat diet. This does not mean high-carb is better for weight loss, but it does show that the body burns more total energy when processing high carbs in an overfed state.
StrongQualifiesHIGH confidence
High carbohydrate overfeeding induced greatest increase in 24-hour EE.
Why this rating
Precise 24-hour indirect calorimetry in a controlled metabolic chamber setting.
Source
Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition
Andrew Perry et al. · JCI Insight · 2024
DOI 10.1172/jci.insight.184279
crossover · n=97Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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