Hormonal
Carriers of the T allele of the rs7903146 TCF7L2 polymorphism experience significantly greater reductions in body fat mass compared to CC homozygotes when treated with carbohydrate-restricted diet alone.
If you are undergoing dietary treatment for blood sugar issues, your genetic makeup (specifically the TCF7L2 gene) may determine how much body fat you lose. Those with the T allele tend to lose significantly more fat than those with the CC genotype. This suggests that personalized dietary advice based on genetics could optimize fat loss outcomes.
In group of diet, T allele carriers of rs7903146 TCF7L2 were characterized with more decrease in fat mass compared with CC homozygotes (- 7.90 ± 9.46% vs. -1.54 ± 8.98%, p = 0.027).
Why this rating
Randomized controlled trial with a small sample size (n=73) and single-center design.
Source
Association of rs7903146 TCF7L2, rs1042714 ADRB2 with the changes in body fat mass in different types of therapy of early carbohydrate metabolism disorders
Ф. В. Валеева et al. · Obesity and metabolism · 2022
DOI 10.14341/omet12807
More from this paper
- Homozgyous carriers of the C allele of the rs1042714 ADRB2 polymorphism experience significantly greater reductions in hip circumference compared to G allele carriers when treated with metformin and diet.Moderate
- TCF7L2 and ADRB2 polymorphisms do not significantly influence total body weight changes in patients undergoing diet or metformin therapy.Moderate
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