Research
Mixed
TCF7L2 and ADRB2 polymorphisms do not significantly influence total body weight changes in patients undergoing diet or metformin therapy.
While your genetics (TCF7L2 and ADRB2) may influence where you lose fat or how your body shape changes, they do not appear to affect your total body weight during diet or metformin therapy. Focus on body composition rather than just the scale.
ModerateRefutesMEDIUM confidence
The association of rs7903146 TCF7L2 and rs1042714 ADRB2 with changes in total body weight was not observed (p> 0.05).
Why this rating
Randomized controlled trial with a small sample size (n=73) and single-center design.
Source
Association of rs7903146 TCF7L2, rs1042714 ADRB2 with the changes in body fat mass in different types of therapy of early carbohydrate metabolism disorders
Ф. В. Валеева et al. · Obesity and metabolism · 2022
DOI 10.14341/omet12807
rct · n=73Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Carriers of the T allele of the rs7903146 TCF7L2 polymorphism experience significantly greater reductions in body fat mass compared to CC homozygotes when treated with carbohydrate-restricted diet alone.Moderate
- Homozgyous carriers of the C allele of the rs1042714 ADRB2 polymorphism experience significantly greater reductions in hip circumference compared to G allele carriers when treated with metformin and diet.Moderate
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