Research
Hormonal
Long-term use of FDA-approved anti-obesity medications (AOMs) is necessary to maintain weight loss, as discontinuation leads to significant weight regain.
If you are using medication to lose weight, plan to use it long-term. Stopping the medication usually causes the weight to come back, along with the health risks. Work with your doctor to find a safe, sustainable long-term plan.
StrongSupportsVERY_HIGH confidence
Continuing the use of long-term approved medications even after weight loss can help with weight maintenance... If medication is discontinued, weight regain occurs and improved comorbidities worsen... It is desirable to administer long-term medication rather than short-term treatment, provided there are no issues with patient tolerance and safety.
Why this rating
Supported by multiple pivotal Phase 3 trials (STEP 1, STEP 5, STEP 4, SURMOUNT) demonstrating sustained efficacy and significant regain upon discontinuation.
Source
Strategies for Long-Term Weight Loss and Maintenance
Yoo Bin Seo · Korean Journal of Family Practice · 2023
narrative_reviewCited 2×
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