Micronutrients & recovery
Oral supplementation with a specific ratio of three amino acids (3 Glycine : 1 Proline : 1 Hydroxyproline), combined with Vitamin C, astaxanthin, and alpha-ketoglutarate, reduces biological age by approximately 1.4 years in humans over a 6-month period and improves skin texture, hydration, and elasticity within 1-3 months.
Take a daily supplement containing a 3:1:1 ratio of Glycine, Proline, and Hydroxyproline, combined with Vitamin C, Astaxanthin, and Alpha-Ketoglutarate. This specific combination was shown to improve skin texture, hydration, and elasticity within 1-3 months, and reduce biological age by about 1.4 years over 6 months in a clinical trial. It is generally safe, though a small percentage of users may experience mild side effects like rosacea or intestinal reactions.
In a clinical observational trial (ISRCTN93189645, 03.07.2025), oral supplementation in humans demonstrated improved skin features within three months and a reduction in biological age by 1.4 years (p = 0.04) within 6 months.
Why this rating
The human data comes from an observational trial with a relatively small sample size (n=45 for biological age) and potential confounders, though supported by robust preclinical data.
Source
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
Alexander Dakhovnik et al. · npj Aging · 2025
DOI 10.1038/s41514-025-00280-7
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