Micronutrients & recovery
Daily oral supplementation with 714 mg nicotinamide and 19 mg pyridoxine accelerates muscle regeneration by increasing muscle stem cell (MuSC) activation and differentiation following eccentric muscle damage.
If you suffer from muscle damage (e.g., from intense exercise or injury), taking 714 mg of Nicotinamide and 19 mg of Pyridoxine daily for about a week may help your body repair muscle faster by boosting stem cell activity. This is distinct from other B3 forms like Nicotinamide Riboside, which may not be effective at these specific cellular targets. Ensure you are healthy and not taking other B-vitamin supplements before starting.
Daily oral NAM/PN supplementation following eccentric muscle damaging contractions enhances MuSC activity and accelerates muscle regeneration.
Why this rating
Randomized, double-blind, placebo-controlled clinical trial, but the paper is a preprint not yet peer-reviewed.
Source
Nicotinamide and Pyridoxine supplementation stimulates muscle stem cells in a randomized clinical trial on muscle repair
Grith Højfeldt et al. · medRxiv · 2025
DOI 10.1101/2025.03.24.25323226
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