Research
Mixed
Dysbiosis (specifically reduced SCFA-producing bacteria and increased pro-inflammatory taxa) contributes to the pathogenesis of Type 2 Diabetes through mechanisms involving gut permeability, LPS-driven inflammation, and impaired insulin signaling.
Maintaining gut health through a fiber-rich diet may help manage blood sugar levels by reducing inflammation and improving insulin sensitivity. This is particularly relevant for those with or at risk for Type 2 Diabetes.
ModerateSupportsMEDIUM confidence
T2DM is generally linked with elevated concentrations of pro-inflammatory molecules, with LPS being a well-established promoter of mild inflammation. A number of investigations have reported an elevated concentration of LPS in peripheral circulation of T2DM patients.
Why this rating
Based on multiple observational and mechanistic studies cited in the review.
Source
Modulating Metabolic Health and Physiological Functions: Advances in Dietary Interventions Targeting Gut Microbiota
Syed Arman Rabbani et al. · Therapeutics and Clinical Risk Management · 2025
DOI 10.2147/tcrm.s540144
narrative_reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Dietary interventions that modulate gut microbiota composition (specifically increasing SCFA-producing bacteria and reducing dysbiosis) improve metabolic health outcomes including insulin sensitivity and glucose tolerance.Moderate
- High-fat diets induce gut barrier defects and metabolic endotoxemia (elevated LPS), which triggers low-grade inflammation and compromises insulin sensitivity.Moderate
Related findings · Mixed
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