Research
Macro partitioning
There is no significant evidence that total fat intake or protein intake interacts with polygenic risk to affect BMI, based on pooled meta-analyses.
Don't rely on simply increasing total protein or total fat to manage genetic obesity risk. The evidence suggests that the specific type of fat (omega-3 vs. trans/SFA) is the key dietary lever, not the total amount of protein or fat.
GoodRefutesMEDIUM confidence
No significant interactions were identified in meta- analyses of PRS interactions with total fat intake and protein intake on BMI.
Why this rating
This is a direct finding from the meta-analysis of the review, though the number of studies included in the meta-analysis was small.
Source
Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta‐Analysis of Observational Studies
Guiomar Masip et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13941
Meta-analysis · 26 studiesCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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