Research
Macro partitioning
There is no significant evidence that total fat intake or protein intake interacts with polygenic risk to affect BMI, based on pooled meta-analyses.
Don't rely on simply increasing total protein or total fat to manage genetic obesity risk. The evidence suggests that the specific type of fat (omega-3 vs. trans/SFA) is the key dietary lever, not the total amount of protein or fat.
GoodRefutesMEDIUM confidence
No significant interactions were identified in meta- analyses of PRS interactions with total fat intake and protein intake on BMI.
Why this rating
This is a direct finding from the meta-analysis of the review, though the number of studies included in the meta-analysis was small.
Source
Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta‐Analysis of Observational Studies
Guiomar Masip et al. · Obesity Reviews · 2025
Meta-analysis · 26 studiesCited 2×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →