Mixed
Personalized nutrition targeting inflammation (PNi) significantly improves body weight, body fat, and inflammatory biomarkers (IL-10, TNF-α, CRP) specifically in individuals with a high genetic predisposition to inflammation (High-PGSi), whereas generic or carbohydrate-focused personalized diets do not yield these specific anti-inflammatory benefits in this subgroup.
If you have a family history of inflammatory conditions or obesity, generic 'healthy eating' advice might not be enough. This research suggests that identifying your genetic risk for inflammation (via a Polygenic Score) allows you to choose a specific anti-inflammatory diet (rich in specific oils, turmeric, and omega-3/6 fats) that can significantly improve your weight, body fat, and inflammatory markers. Without this genetic targeting, standard personalized diets may fail to reduce inflammation in high-risk individuals.
These individuals demonstrated the most effective response to the dietary plan, experiencing improved body composition, with significant decreases in body weight (∆%: –5.8; D × G, P = 0.007) and body fat (∆%: –4.84; D × G, P = 0.039), and beneficial changes in pro- and anti-inflammatory biomarkers, with significant increases in IL-10 (∆%: 71.3; P = 0.025) and decreases in TNF-α (∆%: –4.2; P = 0.048) and MCP1 (∆%: –3.0; P = 0.039) circulating levels, compared to low-PGSi individuals.
Why this rating
Randomized controlled trial secondary analysis with genetic stratification, but post-hoc nature and moderate sample size (n=80 complete) limit generalizability.
Source
Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVENTOMICS intervention
Sebastiá Galmés et al. · Food Science and Human Wellness · 2024
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