Research

Energy balance

Following behavioral weight loss, the body enters a physiological state characterized by adaptive thermogenesis (declines in energy expenditure beyond those attributable to changes in body composition) and increased energy intake, which drive weight regain.

After losing weight, your body biologically fights to regain it by lowering your energy expenditure and increasing hunger. This is a normal physiological response, not a personal failure. To maintain weight loss, you must account for these biological changes, likely requiring ongoing behavioral support and potentially adjusted energy intake/expenditure strategies, rather than relying on the same intensity of effort used during the weight loss phase.

GoodSupportsHIGH confidence
Adaptive thermogenesis [declines in energy expenditure (EE) beyond those attributable to changes in body composition or time spent in physical activity (PA)] and increased energy intake (EI) reported to occur with BWL have been hypothesized to play a role
Michael Rosenbaum et al. · International Journal of Obesity · 2025

Why this rating

The paper describes a rigorous observational study design (POWERS) using gold-standard measures (DLW, DXA) to assess these variables, though it is a protocol paper and not yet a results paper.

Source

The Physiology Of the WEight Reduced State (POWERS) study: assessing energy balance

Michael Rosenbaum et al. · International Journal of Obesity · 2025

DOI 10.1038/s41366-025-01935-x

clinical_guideline · n=205Cited 1×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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