Research
Hormonal
Maintaining weight loss induced by anti-obesity drugs may require lifelong use unless effective adjunct strategies for weight maintenance are available.
If you use medication for weight loss, understand that it may need to be long-term. This is similar to managing other chronic conditions. The goal of research like POWERS is to find adjunct strategies that might reduce this dependency.
ModerateConditionalMEDIUM confidence
maintaining the weight-reduced state induced by these currently expensive and prescription-only drugs may require lifelong use, unless alternative effective adjunct strategies for weight maintenance are available
Why this rating
It is a statement of current clinical reality/consensus, not a new finding from this study.
Source
The Physiology Of the WEight Reduced State (POWERS) study: overview and study design
Steven H. Belle et al. · International Journal of Obesity · 2025
DOI 10.1038/s41366-025-01932-0
clinical_trial · n=205Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intentional weight loss induces physiological adaptations in energy expenditure and intake that actively oppose weight maintenance, contributing to weight regain.Moderate
- Metabolic adaptation (energy expenditure below expected levels) and appetite adaptation (increased energy intake) are coregulated and inseparable factors in weight regain.Moderate
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →