Research
Energy balance
Metabolic adaptation (energy expenditure below expected levels) and appetite adaptation (increased energy intake) are coregulated and inseparable factors in weight regain.
Don't try to fix weight maintenance by only focusing on diet or only on exercise. Your body's hunger signals and energy burn are linked. Effective long-term strategies need to address both sides of the energy balance equation simultaneously.
ModerateQualifiesMEDIUM confidence
These adaptations should be studied together, as they are likely coregulated and inseparable… moving the set point toward a healthy weight may be an important therapeutic goal
Why this rating
Based on workshop consensus and prior literature cited, not yet POWERS data.
Source
The Physiology Of the WEight Reduced State (POWERS) study: overview and study design
Steven H. Belle et al. · International Journal of Obesity · 2025
DOI 10.1038/s41366-025-01932-0
clinical_trial · n=205Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intentional weight loss induces physiological adaptations in energy expenditure and intake that actively oppose weight maintenance, contributing to weight regain.Moderate
- Maintaining weight loss induced by anti-obesity drugs may require lifelong use unless effective adjunct strategies for weight maintenance are available.Moderate
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →