Energy balance
Using different prediction equations (Katch-McArdle vs. BIA-derived) to estimate Resting Metabolic Rate (RMR) during weight loss yields significantly different conclusions regarding the presence of metabolic adaptation (MA), with Katch-McArdle suggesting increased metabolic efficiency (increased aRMR) while BIA suggests decreased efficiency (decreased aRMR).
When tracking weight loss, do not rely on a single prediction equation to judge your metabolic health. This study shows that different formulas can contradict each other regarding metabolic adaptation. To minimize this error, prioritize preserving fat-free mass (muscle) through adequate protein intake (approx. 2.0 g/kg FFM as used in the study) and resistance training, as this stabilizes the metabolic rate more reliably than any single calculation method.
The use of different prediction equations might account for variations in MA in this study. ... While BIA-determined aRMR generally showed decreasing trends across the follow-up periods, only Week 12 demonstrated a statistically significant inverse association compared with the baseline ... A small but statistically significant increase in Katch-McArdle-determined aRMR ... was confirmed by linear mixed models.
Why this rating
Based on a secondary analysis of a randomized clinical trial with 131 participants, adjusted for multiple confounders, though limited by the use of prediction equations rather than direct calorimetry for the primary outcome.
Source
Metabolic adaptation fluctuates with different prediction equations: a secondary analysis based on a weight-loss clinical trial
Molian Tang et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1543263
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