Research
Mixed
Strategies to minimize muscle loss during GLP-1 therapy include increasing protein intake to ≥1.2 g/kg/day and engaging in resistance training 2-3 times per week.
To keep your muscles while losing weight on these drugs, eat at least 1.2 grams of protein per kilogram of your body weight every day. Also, lift weights or do resistance exercises 2-3 times a week. This combination helps protect your strength and metabolic rate.
GoodSupportsHIGH confidence
One of the ways to achieve this is to increase protein intake... In the recommendations of the American Association of Clinical Endocrinologists (AACE, 2025), it is proposed to maintain protein intake at ≥ 1.2 g/kg body weight per day... Another strategy for maintaining muscle mass during weight loss is physical exercise... It is recommended to perform them no less than 2-3 days a week with the aim of maintaining or improving lean body mass.
Why this rating
Based on AACE guidelines and general exercise physiology principles cited in the review.
Source
The impact of semaglutide and tirzepatide on skeletal muscle: Significant benefit or substantial risk?
В. В. Салухов et al. · Meditsinskiy sovet = Medical Council · 2025
DOI 10.21518/ms2025-467
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →