Mixed
Resistance training-induced skeletal muscle hypertrophy is associated with the differential regulation of 110 non-coding RNA (ncRNA) genes, which mediate growth via specific cell types including leukocytes, satellite cells, and pericytes.
This research confirms that muscle growth is not just about mechanical tension but involves complex genetic regulation via non-coding RNAs. For the average lifter, this means individual genetic variability plays a huge role in response to training (only 61% were 'responders' in this study). While there is no direct intervention yet, this highlights that 'non-responders' may have different molecular profiles, suggesting future personalized training or nutritional strategies could be based on these biomarkers.
We completed five human resistance-training studies (n=144 subjects) to stimulate growth, and found 61% of individuals successfully accrued muscle mass... One hundred and ten ncRNAs were modulated in vivo and a network model of the muscle transcriptome (n=437) assigned these to functional pathways or single-cell types.
Why this rating
High-quality multi-cohort human data (n=144) with rigorous filtering and spatial validation, though it is a preprint.
Source
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Jonathan C. Mcleod et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024
DOI 10.1101/2024.08.11.606848
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