Mixed
Intensive lifestyle interventions (ILI) targeting weight loss and physical activity in older adults (≥70 years) with type 2 diabetes and obesity are associated with increased odds of severe mobility disability compared to diabetes support and education (DSE).
For adults over 70 with type 2 diabetes, aggressive weight loss programs may increase the risk of severe mobility disability compared to standard diabetes education. Focus should shift towards preserving functional status and muscle mass rather than prioritizing significant weight reduction, as the loss of lean mass can outweigh the benefits of fat loss for mobility in this age group.
ILI was associated with greater severe mobility disability in participants ≥70. Regardless of age, those with higher BMI had increased late-life mobility and IADL disability.
Why this rating
Based on a large, long-term randomized controlled trial (Look AHEAD) with extended follow-up, though self-reported disability measures are used.
Source
Late-life disability following the action for health in diabetes (Look AHEAD) trial
Charles Semelka et al. · The Journals of Gerontology Series A · 2025
DOI 10.1093/gerona/glaf245
Related findings · Mixed
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