Energy balance
A weight gain of ≥5% over a 3-year period significantly increases the risk of incident type 2 diabetes, while a weight loss of ≥5% significantly decreases it, independent of attained weight.
To lower your risk of type 2 diabetes, aim for a weight change of at least 5% of your body weight over a few years. Losing 5% or more significantly reduces your risk, while gaining 5% or more significantly increases it. This benefit exists regardless of your final weight, meaning the act of changing your weight matters for your metabolic health.
Weight gain and loss of ≥ 5% were associated with increased and decreased risks of incident T2DM, respectively, regardless of attained weight.
Why this rating
Large cohort (n=6930), longitudinal design (up to 9 years), objective measurements, and robust adjustment for confounders, though observational nature prevents definitive causality.
Source
Weight change and risk of incident type 2 diabetes: short, medium and long-term follow-up in tehran lipid and glucose study
Samaneh Asgari et al. · Cardiovascular Diabetology · 2024
DOI 10.1186/s12933-024-02297-w
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