Research
Energy balance
Intensive lifestyle intervention in overweight/obese type 2 diabetic patients significantly reduces the risk of nephropathy, eye disease, sleep apnea, and hospitalizations, even if it does not reduce major cardiovascular events.
Stick with your weight loss and exercise plan. Even if it doesn't lower your heart attack risk, it significantly lowers your risk of kidney disease, eye problems, sleep apnea, and hospital stays. These are major quality-of-life improvements.
StrongSupportsHIGH confidence
Other benefits of weight loss and exercise include 14% decrease in eye disease, less obstructive sleep apnea, improved sexual dysfunction in women, fewer hospitalizations, and less urinary incontinence... nephropathy... was 31% lower in the ILI group.
Why this rating
Based on the same high-quality Look AHEAD trial data.
Source
Look Action for Health in Diabetes trial: What we have learned in terms of real world practice and clinical trials
Ching‐Fai Kwok et al. · Journal of Diabetes Investigation · 2014
DOI 10.1111/jdi.12231
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intensive lifestyle intervention (caloric restriction and increased physical activity) aiming for ≥7% weight loss in overweight/obese adults with type 2 diabetes does not significantly reduce the rate of major cardiovascular events or mortality compared to diabetes support and education, despite significant improvements in intermediate risk factors.Strong
- A Mediterranean-style diet rich in monounsaturated and polyunsaturated fats, polyphenols, and alpha-linolenic acid is associated with a substantially reduced risk of cardiovascular disease and new cancers.Good
Related findings · Energy balance
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