Research
Mixed
The specific repetition scheme used in Low-Load Resistance Training with Blood Flow Restriction (LL-RT with BFR) does not significantly affect muscle hypertrophy outcomes when compared to High-Load Resistance Training.
You can choose your preferred repetition scheme for BFR training (whether to failure, 15 reps, or 75 reps) without worrying about which is 'best' for muscle growth. Focus on consistency and comfort.
GoodSupportsHIGH confidence
It is noteworthy that the effect of LL-RT with BFR versus HL-RT on muscle hypertrophy seems to be unaffected by the repetition scheme adopted in LL-RT with BFR, as shown in our subgroup analyses.
Why this rating
Consistent results across multiple subgroup analyses with low heterogeneity.
Source
Hypertrophic effects of low-load blood flow restriction training with different repetition schemes: A systematic review and meta-analysis
Victor Sabino de Queirós et al. · Research Square · 2023
DOI 10.21203/rs.3.rs-3419589/v1
Meta-analysis · 23 studies
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Low-load resistance training with blood flow restriction (LL-RT with BFR) produces muscle hypertrophy equivalent to high-load resistance training (HL-RT) across various repetition schemes, including sets to failure, 15-rep sets, and 75-rep segmented sets.Good
- For upper limb exercises, High-Load Resistance Training (HL-RT) produces significantly greater muscle hypertrophy than Low-Load Resistance Training with Blood Flow Restriction (LL-RT with BFR).Moderate
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