Mixed
Consumption of an ultra-processed dietary pattern (80% UPFs) induces significant alterations in plasma and urine metabolomic profiles compared to an unprocessed dietary pattern, affecting pathways such as glutamate, bile acid, and fatty acid metabolism.
Even if you match the protein and carbs, eating ultra-processed foods changes your body's internal chemistry differently than whole foods. Look for changes in metabolites related to bile acids and amino acids, which may signal different metabolic stressors.
We identified exogenous and endogenous metabolites, representing a range of metabolic pathways, that consistently differed between a UPF-DP and UN-DP.
Why this rating
Randomized controlled crossover feeding trial with matched macronutrients, though sample size is small (n=20).
Source
Plasma and Urine Metabolomic Response to an Ultra-Processed Dietary Pattern: A Biomarker Discovery Analysis in a Domiciled Randomized Controlled Crossover Feeding Trial
Lauren E O’Connor et al. · Current Developments in Nutrition · 2022
DOI 10.1093/cdn/nzac054.038
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