Hormonal
Tirzepatide (a dual GIP/GLP-1 receptor agonist) administered weekly via subcutaneous injection significantly reduces HbA1c and body weight in adults with type 2 diabetes compared to placebo, semaglutide, and insulin.
If you have type 2 diabetes, a once-weekly injection called tirzepatide can significantly lower your blood sugar and help you lose weight, often more effectively than insulin or other common diabetes medications. While you might experience some stomach upset initially, it usually gets better, and the benefits for your heart and liver are also promising.
SURPASS-1 investigated tirzepatide monotherapy... HbA1c reductions were 21mmol/mol (1.9%), 21mmol/mol (1.9%) and 23mmol/mol (2%) with 5mg, 10mg and 15mg tirzepatide respectively. A dose dependent weight loss of 7–9.2kg was seen.
Why this rating
Based on multiple phase 3 double-blind randomized controlled trials (SURPASS series).
Source
Promising outcomes from latest landmark diabetes trials: tirzepatide and finerenone in the spotlight
Lakshmi Sankaran et al. · Practical Diabetes · 2023
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