Research
Hormonal
Semaglutide (2.4mg weekly) leads to significant weight loss in adults with obesity or overweight, and maintaining treatment prevents weight regain.
For obesity, a once-weekly injection of semaglutide (2.4mg) can help you lose a significant amount of weight (15-20%). However, if you stop taking it, you will likely regain most of the weight, so it is intended for long-term use.
StrongSupportsHIGH confidence
randomisation to ongoing 48-weeks semaglutide showed 7.9% further weight loss (total 17.4%) whereas the placebo arm regained two-thirds of their loss (6.9%).
Why this rating
Based on phase 3 double-blind randomised trials (STEP series).
Source
Promising outcomes from latest landmark diabetes trials: tirzepatide and finerenone in the spotlight
Lakshmi Sankaran et al. · Practical Diabetes · 2023
DOI 10.1002/pdi.2432
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide (a dual GIP/GLP-1 receptor agonist) administered weekly via subcutaneous injection significantly reduces HbA1c and body weight in adults with type 2 diabetes compared to placebo, semaglutide, and insulin.Strong
- Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduces cardiovascular and renal risks in patients with type 2 diabetes and chronic kidney disease.Strong
- Incretin-based treatments (semaglutide, dulaglutide) are effective and safe in adolescents with obesity or type 2 diabetes.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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