Research
Hormonal
Semaglutide (2.4mg weekly) leads to significant weight loss in adults with obesity or overweight, and maintaining treatment prevents weight regain.
For obesity, a once-weekly injection of semaglutide (2.4mg) can help you lose a significant amount of weight (15-20%). However, if you stop taking it, you will likely regain most of the weight, so it is intended for long-term use.
StrongSupportsHIGH confidence
randomisation to ongoing 48-weeks semaglutide showed 7.9% further weight loss (total 17.4%) whereas the placebo arm regained two-thirds of their loss (6.9%).
Why this rating
Based on phase 3 double-blind randomised trials (STEP series).
Source
Promising outcomes from latest landmark diabetes trials: tirzepatide and finerenone in the spotlight
Lakshmi Sankaran et al. · Practical Diabetes · 2023
narrative_review
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