Research
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Caloric restriction through structured dietary interventions improves functional capacity and quality of life in patients with HFpEF.
For HFpEF patients, structured caloric restriction programs that provide all meals can lead to significant weight loss and improved heart function. This approach is supported by guidelines and can be a viable alternative or adjunct to medication.
ModerateSupportsMEDIUM confidence
In HF with preserved ejection fraction (HFpEF), the largest diet-driven randomised trial (SECRET; n = 100) of a dietary intervention (caloric restriction (provision of all foods in a university setting)) resulted in 7 kg weight loss and improved 6-min walk distance, peak oxygen uptake, health status, and regression in left ventricular mass, compared to those who did not undergo the diet intervention [4].
Why this rating
Based on a single randomized trial (SECRET, n=100) with modest sample size.
Source
Appetite and its Regulation: Are there Palatable Interventions for Heart Failure?
Matthew M.Y. Lee et al. · Current Heart Failure Reports · 2023
DOI 10.1007/s11897-023-00637-7
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- GLP-1 receptor agonists (specifically semaglutide) produce substantial, sustained weight loss and improve health status in patients with heart failure with preserved ejection fraction (HFpEF).Good
- GLP-1 receptor agonists (liraglutide) have unclear clinical benefits in non-obese patients with Heart Failure with Reduced Ejection Fraction (HFrEF).Limited
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