Research
Energy balance
Bariatric surgery (Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass) provides effective and sustainable weight loss, with Roux-en-Y showing greater long-term excess weight loss but higher morbidity.
If you have severe obesity (BMI >40 or >35 with health issues), surgery is a highly effective option. Gastric Bypass leads to more weight loss than Sleeve Gastrectomy but has higher risks. Discuss the trade-offs with your surgeon.
GoodQualifiesHIGH confidence
The results indicated that in a follow-up after 7 years, the mean percentage of excess weight loss was higher after LRYGB (55%) than after LSG (47%). Although LRYGB resulted in greater weight loss, it was associated with a 4.6% higher total morbidity rate.
Why this rating
Based on cited randomized controlled trials comparing two surgical procedures.
Source
Obesity and Current Treatment Approaches: A Comprehensive Review
Karthik Mathialagan et al. · Journal of Translational Gastroenterology · 2024
DOI 10.14218/jtg.2023.00040
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Weekly subcutaneous semaglutide (2.4 mg) produces significantly greater mean weight loss (15.4%) compared to daily subcutaneous liraglutide (3.0 mg, 6.4%) in patients with overweight or obesity.Good
- Tirzepatide, a dual GIP and GLP-1 receptor agonist, produces greater weight loss than Semaglutide in patients with type 2 diabetes.Good
- Combination pharmacotherapy for obesity is significantly more effective than monotherapy.Moderate
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →