Mixed
Adherence to a prudent diet high in raw vegetables, fruits, and berries significantly attenuates the increased risk of myocardial infarction and cardiovascular disease associated with Chromosome 9p21 genetic variants.
If you have a family history of heart disease or know you carry the 9p21 genetic variant, your diet matters more than for the general population. To neutralize this specific genetic risk, you must eat fresh vegetables, fruits, and berries daily. Doing so reduces your genetic risk to baseline levels, whereas a poor diet doubles your risk of a heart attack.
The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits.
Why this rating
Large-scale multi-ethnic case-control (INTERHEART) and prospective cohort (FINRISK) studies with consistent findings across populations.
Source
The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study
Ron Do et al. · PLoS Medicine · 2011
DOI 10.1371/journal.pmed.1001106
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