Research
Hormonal
Anti-obesity medications (AOMs) including liraglutide, semaglutide, and tirzepatide demonstrate efficacy and safety for chronic weight management in randomized controlled trials lasting over one year.
If you are prescribed an FDA-approved anti-obesity medication like semaglutide or tirzepatide, expect it to be a long-term treatment. These drugs have been shown to be safe and effective for weight management over periods of 1-5 years in clinical trials. Because obesity is chronic, stopping the medication often leads to weight regain, so plan for ongoing use and address insurance/access issues early.
StrongSupportsHIGH confidence
A significant body of evidence from randomized controlled trials has supported the efficacy and safety of Food and Drug Administration (FDA)-approved AOMs for chronic weight management, including liraglutide (2014), semaglutide (2021), and tirzepatide (2023).
Why this rating
Cites multiple large-scale, long-duration RCTs (SCALE, SELECT, SURMOUNT-4).
Source
Response to the Letter to the Editor by Bett et al.
Jaime P. Almandoz et al. · Obesity · 2024
narrative_review
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →