Research
Mixed
Dietary fiber intake must be accompanied by adequate water intake to prevent constipation, a common adverse event of anti-obesity medications.
When taking weight loss medications, increase your intake of fruits, vegetables, and whole grains for fiber, but you MUST drink more water. Without enough fluid, high fiber can cause constipation, which is already a common side effect of these drugs.
GoodQualifiesHIGH confidence
We agree that dietary fiber intake without adequate water intake could lead to constipation and noted in our review the importance of attention to both fiber and fluid intake.
Why this rating
Based on clinical consensus and review of adverse events, not a primary RCT outcome.
Source
Response to the Letter to the Editor by Bett et al.
Jaime P. Almandoz et al. · Obesity · 2024
DOI 10.1002/oby.24140
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Anti-obesity medications (AOMs) including liraglutide, semaglutide, and tirzepatide demonstrate efficacy and safety for chronic weight management in randomized controlled trials lasting over one year.Strong
- Energy intake goals for obesity treatment should be personalized, but general guidance based on sex is currently the standard in evidence-based guidelines.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →