Mixed
Semaglutide improves patient-reported pain and function in chronic plantar heel pain, with approximately half of the benefit mediated by weight loss.
If you have chronic heel pain and are overweight or have Type 2 Diabetes, ask your doctor if GLP-1 medications like semaglutide might help. The study suggests these drugs can reduce pain and improve foot function, largely by helping you lose weight, which reduces stress on your feet. This is not a standard treatment yet, so discuss the risks and benefits with your provider.
The association of semaglutide exposure with improvement in FHSQ pain/function subdomain was substantially mediated by the BMI reduction (mediation proportion: FHSQ pain subdomain, 52.6% [36.2% to 79.0%], P <0.001; FHSQ function subdomain, 56.6% [39.9% to 82.0%], P <0.001)
Why this rating
Observational cohort and small pilot interventional study; lacks randomized controlled trial design.
Source
Association of semaglutide use with outcomes in chronic plantar heel pain: a prospective observational cohort and a pilot interventional study
Fan Yang et al. · International Journal of Surgery · 2025
DOI 10.1097/js9.0000000000003156
Related findings · Mixed
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