Mixed
Tirzepatide treatment yields greater improvements in physical function for patients with lower baseline physical function scores compared to those with higher baseline scores, despite similar magnitude of weight loss across all baseline levels.
If you have obesity and struggle with physical function (e.g., difficulty walking, climbing stairs), starting tirzepatide is highly recommended. You will likely lose weight just as effectively as someone who is more active, and you may experience the most dramatic improvements in your daily physical capabilities. Do not let current mobility issues stop you from seeking treatment.
Participants with lower baseline PF reported greater improvements in PF with tirzepatide (Q1 = 12.5; Q4 = −0.8). Results were similar in SURMOUNT- 3 and SURMOUNT- 4.
Why this rating
Based on pooled data from three large phase 3 randomized controlled trials (SURMOUNT-1, -3, -4) with over 3,700 participants, though the analysis is post hoc.
Source
People With Lowest Physical Functioning Scores Showed Greatest Improvement After Tirzepatide Treatment
Xuan Li et al. · Obesity · 2025
DOI 10.1002/oby.70067
Related findings · Mixed
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