Mixed
Higher physical activity levels significantly attenuate the genetic predisposition to obesity associated with the FTO rs1421085 risk allele, reducing its effect on BMI and body adiposity by 36–75%.
If you carry the FTO obesity risk gene, regular physical activity is your most effective tool to counteract that genetic predisposition. The study shows that being active can reduce the genetic impact on your body fat by up to 75%. Focus on consistent movement to mitigate your genetic risk.
Our results show that physical activity can blunt the genetic effect of FTO rs1421085 on adiposity by 36–75% in a longitudinal multi-ethnic cohort.
Why this rating
Large longitudinal multi-ethnic cohort (n=17,423) with quantitative PA measures and genetic analysis, though interaction terms were nominally significant.
Source
Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study
Hudson Reddon et al. · Scientific Reports · 2016
DOI 10.1038/srep18672
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