Research

Energy balance

Adhering to national dietary guidelines using minimally processed foods (MPF) results in significantly greater weight loss and fat mass reduction compared to adhering to the same guidelines using ultraprocessed foods (UPF), primarily driven by lower energy intake.

If you want to lose weight, follow your country's official healthy eating guidelines. Doing so with minimally processed foods (like whole grains, fresh fruits, and vegetables) will help you lose more weight than doing so with ultraprocessed foods (like reformulated cereals and ready meals). However, even if you eat ultraprocessed foods, as long as they meet national nutritional standards (low sugar, salt, and fat, high fiber), you can still lose weight. The key is that minimally processed foods help you eat fewer calories naturally, likely because they are less energy-dense and take longer to eat.

StrongSupportsHIGH confidence
MPF (%WC, −2.06 (95% confidence interval (CI), −2.99, −1.13) and UPF (%WC, −1.05 (95% CI, −1.98, −0.13)) resulted in weight loss, with significantly greater %WC on MPF (Δ%WC, −1.01 (95% CI, −1.87, −0.14), P = 0.024; Cohen’s d, −0.48 (95% CI, −0.91, −0.06)).
Samuel J. Dicken et al. · Nature Medicine · 2025

Why this rating

Randomized, crossover, controlled feeding trial with high adherence and blinded outcomes.

Source

Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial

Samuel J. Dicken et al. · Nature Medicine · 2025

crossover · n=55Cited 59×
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