Hormonal
High baseline and post-intervention levels of circulating microRNA-935 (c-miR-935) are associated with low weight loss response (<5% body mass loss) to a combined diet and exercise intervention, whereas high responders (>10% loss) exhibit lower levels.
If you are following a structured diet and exercise plan and seeing very little weight loss despite good adherence, your body's molecular response (specifically c-miR-935 levels) might be blunting your results. This doesn't mean the plan is wrong for you, but it may need adjustment. Consult a professional to see if biomarker testing or protocol modification (e.g., increasing the energy deficit or changing exercise type) is warranted.
Expression of c-miR-935 was higher in LoRes compared to HiRes pre- (~47%; P = 0.025) and post- (~100%; P<0.01) intervention and was the only c-miRNA differentially expressed at baseline between groups.
Why this rating
Randomized controlled trial design with a clear distinction between high and low responders, though the sample size for the specific subgroups (n=22 HiRes, n=18 LoRes) is moderate.
Source
Circulating MicroRNA Responses between ‘High’ and ‘Low’ Responders to a 16-Wk Diet and Exercise Weight Loss Intervention
Evelyn B. Parr et al. · PLoS ONE · 2016
DOI 10.1371/journal.pone.0152545
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