Hormonal
Increases in circulating microRNA-221 (c-miR-221) and microRNA-223 (c-miR-223) abundance occur in both high and low responders to a combined diet and exercise intervention, suggesting these changes are driven by the exercise stimulus rather than the magnitude of weight loss.
Consistent exercise leads to beneficial molecular changes (increased c-miR-221 and -223) regardless of how much weight you lose. These changes are linked to improved energy metabolism and exercise adaptation. Focus on the consistency of the exercise stimulus for these health benefits, even if weight loss is slower than expected.
The abundance of c-miR-221-3p and -223-3p increased pre- to post-intervention in both groups (~57–69% and ~25–90%, P<0.05).
Why this rating
Consistent findings across both responder groups with statistical significance.
Source
Circulating MicroRNA Responses between ‘High’ and ‘Low’ Responders to a 16-Wk Diet and Exercise Weight Loss Intervention
Evelyn B. Parr et al. · PLoS ONE · 2016
DOI 10.1371/journal.pone.0152545
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