Research
Mixed
Microbiome-targeted interventions like prebiotics, probiotics, and synbiotics show potential antihypertensive effects, but results are heterogeneous and require larger randomized trials.
While probiotics and prebiotics show promise, they are not yet a proven standalone treatment for hypertension. Focus on a healthy diet and lifestyle first, and consider these supplements as potential adjuncts under medical guidance.
ModerateQualifiesMEDIUM confidence
Prebiotics, probiotics, synbiotics and faecal microbiota transplantation have demonstrated potential antihypertensive effects in preclinical and clinical studies, although findings are heterogeneous and require confirmation in larger randomised trials.
Why this rating
Based on a narrative review of preclinical and clinical studies with heterogeneous findings.
Source
Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue
Andrej Belančić et al. · Endocrinology Diabetes & Metabolism · 2026
DOI 10.1002/edm2.70159
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Gut microbiota dysbiosis in obesity drives hypertension through intestinal barrier dysfunction, allowing lipopolysaccharide (LPS) translocation that triggers systemic inflammation and vascular damage.Moderate
- Short-chain fatty acids (SCFAs) produced by gut bacteria have complex effects: while generally beneficial for blood pressure regulation via GPCR activation, increased production in obesity may contribute to calorie harvest and weight gain.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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