Hormonal
Incretin-based therapies (GLP-1 and dual/triple agonists) produce clinically significant weight loss (15-21%) and improve cardiometabolic, renal, and hepatic outcomes, marking a turning point in obesity management.
Current GLP-1 and dual agonist medications are highly effective for significant weight loss and improving overall health markers like heart and liver function. They represent a major advancement over lifestyle changes alone, though they require long-term commitment and management of potential side effects like nausea.
The rapid development of highly effective incretin-based therapies has transformed obesity care by achieving clinically significant and substantial weight loss... Incretin-based therapy demonstrates substantial weight loss while also improving cardiometabolic, renal, hepatic, and functional outcomes.
Why this rating
Based on multiple Phase 3 trials (STEP, SURMOUNT, etc.) with large sample sizes and robust statistical significance.
Source
Future Directions in the Medical Treatment of Obesity: A Narrative Review
Aya Bassatne et al. · Advances in Therapy · 2026
DOI 10.1007/s12325-026-03576-6
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