Research
Hormonal
Dual and triple incretin agonists (e.g., Tirzepatide, Retatrutide) achieve greater weight loss than single GLP-1 agonists by targeting multiple hormonal pathways.
Newer dual and triple hormone agonists offer even greater weight loss potential (up to 21%) than single-agonist GLP-1 drugs. They work by targeting multiple appetite and metabolism pathways simultaneously, making them highly effective for significant obesity.
StrongSupportsVERY_HIGH confidence
Emerging therapies, including triple agonists, amylin analogues, and myostatin-activin pathway inhibitors, target complementary hormonal and metabolic pathways and may further enhance weight loss and body composition outcomes.
Why this rating
Supported by Phase 3 trials (SURMOUNT, etc.).
Source
Future Directions in the Medical Treatment of Obesity: A Narrative Review
Aya Bassatne et al. · Advances in Therapy · 2026
narrative_review
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