Research
Energy balance
Lifestyle interventions involving ≥150 minutes of exercise per week combined with caloric restriction are associated with the highest odds of long-term weight loss maintenance (5-10%).
To keep weight off long-term, aim for at least 150 minutes of exercise per week, ideally closer to 275 minutes, while maintaining a healthy diet. This combination offers the best chance of keeping 5-10% of your weight off permanently.
GoodSupportsHIGH confidence
275 min/ week of physical activity when combined with restricted caloric intake was found to be associated with the highest odds of long-term weight loss maintenance of 5-10%.
Why this rating
Based on an RCT (Jakicic et al.) and National Weight Control Registry data.
Source
iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025
Stefan D. Anker et al. · International Journal of Cardiovascular Sciences · 2026
DOI 10.36660/ijcs.20260056
clinical_guideline
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Once-weekly subcutaneous semaglutide 2.4 mg induces significant weight loss (average 14.9% body weight) in non-diabetic adults with overweight or obesity compared to placebo.Strong
- Targeting obesity with GLP-1-based therapies reduces major adverse cardiovascular events (MACE) in patients with established atherosclerotic cardiovascular disease (ASCVD) and overweight/obesity, even without diabetes.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →