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Retatrutide and dual agonists achieved equivalent mean weight loss of -11.0 kg, surpassing GLP-1RAs which had a mean weight loss of -9.0 kg.
Practitioners can expect retatrutide and dual agonists to provide significant weight loss compared to GLP-1RAs.
StrongSupportsmedium confidence
Retatrutide and dual agonists achieved equivalent mean weight loss (-11.0 kg), surpassing GLP-1RAs (-9.0 kg).
Why this rating
The study is a Bayesian network meta-analysis.
Source
Efficacy and Safety of <scp>GLP</scp> ‐1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian <scp>NMA</scp>
Binayak Sinha et al. · Obesity · 2025
DOI 10.1002/oby.24360
Meta-analysisCited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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