Research
Energy balance
Retatrutide and dual agonists achieved equivalent mean weight loss of -11.0 kg, surpassing GLP-1RAs which had a mean weight loss of -9.0 kg.
Practitioners can expect retatrutide and dual agonists to provide significant weight loss compared to GLP-1RAs.
StrongSupportsmedium confidence
Retatrutide and dual agonists achieved equivalent mean weight loss (-11.0 kg), surpassing GLP-1RAs (-9.0 kg).
Why this rating
The study is a Bayesian network meta-analysis.
Source
Efficacy and Safety of <scp>GLP</scp> ‐1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian <scp>NMA</scp>
Binayak Sinha et al. · Obesity · 2025
Meta-analysisCited 10×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →