Research
Metabolic adaptation
Tirzepatide significantly increased fat oxidation while decreasing carbohydrate and protein oxidation rates.
Practitioners may leverage TZP's effects on fat oxidation to optimize weight loss protocols.
StrongSupportsmedium confidence
TZP significantly reduced 24-hr RQ and sleeping RQ compared to PBO; thus, significantly increasing fat oxidation while decreasing carbohydrate and protein oxidation rates.
Why this rating
Based on the randomized controlled trial design.
Source
127-OR: The Effect of Tirzepatide during Weight Loss on Metabolic Adaption, Fat Oxidation, and Food Intake in People with Obesity
Éric Ravussin et al. · Diabetes · 2023
rct · n=55Cited 10×
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