Research
Energy balance
Once-weekly treatment with tirzepatide 10 mg resulted in a mean change in body weight of -13.6% at week 52.
Tirzepatide 10 mg can be an effective option for weight reduction in this population.
StrongSupportsmedium confidence
The mean change in body weight at week 52 was -13.6% (95% CI, -15.8% to -11.4%) with tirzepatide 10 mg.
Why this rating
Based on the randomized, double-blind, placebo-controlled trial design.
Source
Tirzepatide for Weight Reduction in Chinese Adults With Obesity
Lin Zhao et al. · JAMA · 2024
DOI 10.1001/jama.2024.9217
rct · n=210Cited 103×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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