Research
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33.4% of participants randomized to semaglutide achieved ≥20% weight loss compared to 2.2% with placebo.
A significant proportion of patients may achieve substantial weight loss with semaglutide, making it a viable option for obesity management.
StrongSupportsmedium confidence
At longest follow-up, 33.4% of participants randomized to semaglutide achieved ≥20% weight loss compared to 2.2% with placebo (RR: 15.08; 95% CI 9.31, 24.43).
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Areesha Moiz et al. · The American Journal of Cardiology · 2024
DOI 10.1016/j.amjcard.2024.04.041
Meta-analysisCited 77×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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