Research
Metabolic adaptation
Tirzepatide 15 mg had the highest efficacy compared with placebo for achieving ≥15% weight loss (risk ratio 10.24, 95% CI: 6.42-16.34).
Tirzepatide 15 mg is highly effective for significant weight loss in overweight and obese patients.
StrongSupportsmedium confidence
Tirzepatide 15 mg had the highest efficacy compared with placebo for achieving ≥15% weight loss (risk ratio 10.24, 95% CI: 6.42-16.34).
Why this rating
Based on a network meta-analysis of 31 randomized controlled trials.
Source
Efficacy and safety of tirzepatide, <scp>GLP</scp>‐1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta‐analysis
Xin‐Hui Pan et al. · Obesity · 2024
DOI 10.1002/oby.24002
Meta-analysisCited 58×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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