Research
Energy balance
Gastrointestinal adverse events were the most frequently reported but rarely led to treatment discontinuation.
Practitioners should monitor for gastrointestinal side effects but can expect them to be manageable.
StrongSupportsmedium confidence
Gastrointestinal adverse events were the most frequently reported but rarely led to treatment discontinuation.
Why this rating
Based on the multicentre observational study design.
Source
Six‐Month Real‐World Effectiveness, Persistence and Safety of Low‐to‐Moderate Dose Tirzepatide in Adults With Obesity: A Multicentre Observational Study
Nikolaos Angelopoulos et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70810
cohort · n=260Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →