Hormonal
Skeletal muscle-derived myonectin confers protection against ischemia-reperfusion injury in the heart, as endurance training reduces infarct size in wild-type mice but not in myonectin-deficient mice.
Endurance training likely protects your heart against certain types of injury (like those during surgery or heart attack) through the release of myonectin. However, human blood tests for myonectin are inconsistent, so this is a protective mechanism you gain through consistent training, not something you can easily monitor or supplement.
endurance training decreased infarct size after IR in WT, but not in myonectin KO mice, supporting the notion that the training-induced elevation of circulating myonectin confers this protective effect
Why this rating
Strong mechanistic evidence in mice, but human relevance is speculative.
Source
The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
Aurel B. Leuchtmann et al. · Frontiers in Physiology · 2021
DOI 10.3389/fphys.2021.709807
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